A holistic approach in patient management and epidemic surveillance through convergence of diagnostic technologies, capacity building and stakeholder engagementcore
HoliCare · Horizon Europe grant · 2022-09-01–2026-08-31
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-HLTH-2021-DISEASE-04 · scheme HORIZON-RIA · topic HORIZON-HLTH-2021-DISEASE-04-03. CORDIS record →
Objective
Research on Poverty-Related Diseases (PRDs) in sub-Saharan Africa suffers from major technological and non-technological challenges that prevent high quality healthcare to reach many areas. Not only their performance, but also the affordability, manufacturability, suitability for Low- and Middle-Income Countries (LMICs) and deployment of the (few) available diagnostics are main barriers to ensure good quality of healthcare in sub-Saharan Africa. The HoliCare project aims to tackle such challenges from a holistic perspective, by bridging the gap between technological excellence, available infrastructures, capacity, and local uptake of new technologies. We have chosen to work with lower respiratory infections as a blueprint for our new approach due to their huge clinical and socioeconomic impact, and relevance to the SARS-CoV-2 pandemic. Technology-wise, we propose a 2-tiered, digitally interfaced diagnostic approach that will start in the field using multiplexed lateral flow tests for rapid screening and triage, followed by a referral to a hospital (when needed) and a follow-up detailed diagnosis using a POC-Instrument performing simultaneous nucleic acid amplification (LAMP) for pathogen identification and immunoassays for host biomarker quantitation. Digital and manufacturing infrastructures will encompass these technology innovations to ensure future local product development. Quality controlled biobanks will be developed for executing reliable clinical studies. Training and human capital investment will be achieved by focussed and high-level training activities. Adoption and implementation activities will pave the way for the proposed diagnostic solutions to be successfully deployed, fitting the purpose of the local populations. Our developments will be scalable, adaptable and transferrable to other diseases and national (eco) systems, aiming to contribute to the improvement of healthcare delivery in sub-Saharan Africa.
Beneficiaries (16)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| KUNGLIGA TEKNISKA HOEGSKOLAN | SE | coordinator | €1,100,968 | |
| INSTITUT PASTEUR DE DAKAR | SN | participant | €645,310 | |
| KAROLINSKA INSTITUTET | SE | participant | €592,612 | |
| STOCKHOLMS UNIVERSITET | SE | participant | €554,004 | |
| MAKERERE UNIVERSITY | UG | participant | €500,000 | |
| ISTOC OY | FI | participant | €488,750 | Yes |
| BLUMORPHO | FR | participant | €455,000 | Yes |
| MAST DIAGNOSTICA GMBH | DE | participant | €430,000 | Yes |
| ARMAUER HANSEN RESEARCH INSTITUTE | ET | participant | €375,345 | |
| ALBERT-LUDWIGS-UNIVERSITAET FREIBURG | DE | participant | €358,459 | |
| MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY | UG | participant | €313,750 | |
| HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV | DE | participant | €43,576 | |
| TEESSIDE UNIVERSITY | UK | associatedPartner | — | |
| MAC Clinical Research 1 Limited | UK | associatedPartner | — | Yes |
| THE UNIVERSITY OF CUMBRIA LBG | UK | associatedPartner | — | |
| MOLOGIC LTD | UK | associatedPartner | — | Yes |
Get the EU Defence Funding Calendar — free
The full calendar of open EU defence and dual-use funding calls, sorted by deadline, updated nightly. Delivered with DFM Analysis, our weekly briefing on who is funding what in European defence.
Or browse all open defence & dual-use calls on the funding calendar →
Defence Finance Monitor is an analytical and informational product. Grant data is official CORDIS; the paid Annual Professional subscription is handled on DFM Analysis.