DFM Funding Monitor

A unique commercially viable recombinant manufacturing platform for human fibrinogen (rhFib) & thrombin (rhThrbroad

RECOFIB · Horizon Europe grant · 2022-04-01–2023-12-31

EC contribution

€2,500,000

Total cost

€4,495,826

Beneficiaries

1

About the data

Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2021-ACCELERATOROPEN-01 · scheme HORIZON-EIC-ACC-BF · topic HORIZON-EIC-2021-ACCELERATOROPEN-01. CORDIS record →

Objective

We have developed the RECOFIB platform, a market first recombinant production platform for human fibrinogen (rhFib) & thrombin (rhThr). Using Chinese Hamster Ovary Cells (CHO) expression technology & patented upstream purification processes, we are the first producer of fully intact & functional recombinant fibrinogen and active thrombin at commercially acceptable cost ending reliance on blood plasma. Our RECOFIB platform can produce individual fibrinogen variants whose specific functional properties can now be fully harnessed-a breakthrough discovery. From these individual variants, we can develop customized products for [1] bioactive topical hemostats to stop excessive bleeding during surgery; [2] medical implant coating reducing antibiotic resistance of MRSA bacterial biofilms and [3] supply of rhFib variants & rhThr as OEM products. Additional benefits of our rhFib variants compared to plasma fibrinogen include more stability, 10–100X higher purity, and improved safety profile.

Beneficiaries (1)

Organisation	Country	Role	EC contribution	SME
FIBRIANT BV	NL	coordinator	€2,500,000	Yes

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