Human Milk Lactoferrin by Precision Fermentationbroad
HuMiLAF · Horizon Europe grant · 2025-05-01–2027-04-30
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2024-ACCELERATOR-02 · scheme HORIZON-EIC-ACC · topic HORIZON-EIC-2024-ACCELERATORCHALLENGES-04. CORDIS record →
Objective
Precision fermentation presents a transformative solution for today's food system by reducing reliance on animal proteins, offering a sustainable and scalable method for producing specialty proteins. PFx Biotech leverages this innovative technology to produce human milk proteins (HMPs) structurally and functionally identical to those found in human breast milk. This method addresses environmental concerns and ensures higher purity and cost-effectiveness. Proteins like lactoferrin, α-lactalbumin, osteopontin, and immunoglobulins are found in low quantities in cow milk, necessitating the processing of large volumes (e.g., 50 L of milk for 1 g of lactoferrin) and leading to high costs and carbon emissions (50 kg CO2eq). These cow milk-derived proteins also differ by up to 40% in amino acid sequence from their human counterparts, impacting their bioactivity, digestibility, health benefits, and allergenic potential. The infant formula industry is increasingly driven to replicate the composition and bioactivity of human breast milk, but traditional formulas, which use cow milk proteins, fall short due to these structural and functional differences. There is a growing demand for more accurate mimics of human milk to improve infant health outcomes and reduce risks associated with obesity and allergies. The HuMiLAF project aims to scale up the production of human milk lactoferrin (hLF) to a pre-industrial scale, validating its properties and testing its applications. This includes using hLF alone and in micro-and co-encapsulated forms with human milk oligosaccharides (HMOs) and specific probiotic strains in two key products: infant formula and immunity shots. Business objectives include securing regulatory approvals, signing agreements with major customers, and advancing the project to commercialization. This project not only addresses a critical gap in infant nutrition but also positions PFx at the forefront of sustainable and innovative protein production.
Beneficiaries (2)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| PFX BIOTECH LDA | PT | coordinator | €2,499,999 | Yes |
| PFX BIOTECH | BE | thirdParty | €0 | Yes |
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