Multi-organ toxicity and efficacy test platform for Personalized medicine & Drug developmentbroad
ASTEROID · Horizon Europe grant · 2024-09-02–2027-03-01
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2024-ACCELERATOR-02 · scheme HORIZON-EIC-ACC · topic HORIZON-EIC-2024-ACCELERATOROPEN-01. CORDIS record →
Objective
The pharmaceutical and medical fields need more predictive models to assess the effects of drugs on patients. The demand arisesfrom the desire to replace animal tests, enhance predictability, and reduce drug development time and costs. In personalizedmedicine, there's a need for tools like companion diagnostics to identify patients who will benefit and respond from specifictreatments.Recent changes in EU and US regulations, allowing drug candidates to be submitted without animal testing, have led to thedevelopment of alternative solutions like 3D cell culture and organs-on-a-chip. These technologies have shown promise in predictingdrug effects on patients, but 3 scientific challenges persist, namely including functional vascular interfaces, multilayer tissueequivalent reconstruction without PDMS, and cultivating interconnected organs with varying oxygen concentrations. Also, 2industrial bottlenecks on the compatibility with multiwell plate formats and the need for reproducible biological protocols arepresent.Cherry Biotech has developed a 3D cell culture platform that addresses these bottlenecks with three innovations: the MicrofluidicPerfusion Lid (MPL), the Hydroflat, and the Cubix control unit. These innovations have received approval from industrial and hospitalpartners and has been patented in Europe and US.The company aims to address the preclinical drug development (CubiX RUO, 2026) market and the precision medicine market (CubiXCDx, 2030). The preclinical drug development market is growing rapidly due to favorable regulatory changes, while the precisiononcology market is driven by biomarker-based assays for guiding medical treatments.Cherry Biotech's work not only has financial implications but also has a significant impact on human health and animal welfare byoffering predictive models and reducing the need for animal testing. It contributes to technological advancement and innovation inthe EU.
Beneficiaries (1)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| CHERRY BIOTECH | FR | coordinator | €2,499,831 | Yes |
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