A breakthrough active immunotherapy for the treatment of osteoarthritisbroad
Anti-IL-6 · Horizon Europe grant · 2024-03-01–2026-02-28
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2023-ACCELERATOR-01 · scheme HORIZON-EIC-ACC-BF · topic HORIZON-EIC-2023-ACCELERATOROPEN-01. CORDIS record →
Objective
Osteoarthritis is a debilitating disease affecting the joint and a leading cause of disability worldwide. It affects at least 250m people and incurs healthcare costs of toward 0.5% of the GDP. Peptinov is developing an active immunotherapy that can halt inflammation-driven destruction of the cartilage in the joints. We use a unique approach to neutralise a key pro-inflammatory protein (IL-6) driving chronic inflammation. Our vaccine-like approach stimulates the patients own immune system to produce antibodies against excess IL-6 and neutralise its biological function. By doing so we will halt disease progression. Our treatment will cost 5-10% of conventional immunotherapies as we inject patients with inexpensive, immunogenic peptides to stimulate production of endogenous antibodies. Phase I clinical trial yielded very encouraging preliminary safety and tolerability data on 24 patients. This project will implement the Phase II clinical trial and make our therapy out-licensing ready.
Beneficiaries (1)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| PEPTINOV | FR | coordinator | €2,499,999 | Yes |
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