Adpative DBSbroad
alphadbs · Horizon Europe grant · 2023-03-01–2025-02-28
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2022-ACCELERATOR-01 · scheme HORIZON-EIC-ACC-BF · topic HORIZON-EIC-2022-ACCELERATOROPEN-01. CORDIS record →
Objective
Differently from other DBS systems on the market, the AlphaDBS can be programmed with two different types of stimulation: conventional DBS, which is implemented also by other DBS systems, and adaptive DBS (aDBS) that automatically adjusts the energy delivered to patient using a biosignal, local field potential (LFP), in a close loop configuration. LFPs represent the synchronous presynaptic and postsynaptic activity of neuronal populations and can be recorded with the macro-electrodes routinely implanted for cDBS. In Parkinson Disease, LFPs (especially in beta-band) are specifically modulated by dopamine intake, movement execution and preparation, and that they encode non-motor functions, such as decision making. The beta band power represents the input variable to the adaptive algorithm, implemented by the AlphaDBS system, which, every second computes a new stimulation value.
Beneficiaries (1)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| NEWRONIKA SPA | IT | coordinator | €2,499,999 | Yes |
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