Affordable Cryo-EM through Computational Enhancement of Structural Studiesbroad
ACCESS · Horizon Europe grant · 2026-05-01–2029-04-30
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2025-TRANSITIONOPEN · scheme HORIZON-EIC · topic HORIZON-EIC-2025-TRANSITIONOPEN. CORDIS record →
Objective
Cryo-electron microscopy has transformed structural biology, enabling atomic-resolution protein structure determination without crystallization through imaging of flash-frozen specimens in vitreous ice. Despite the 2017 Nobel Prize recognition, current cryo-EM faces critical limitations: minimum protein size requirements (>50-100 kDa), sample homogeneity constraints, and prohibitive costs (€10M+ for 300 kV system and infrastructure from US/Japanese manufacturers). ACCESS radically reimagines this paradigm through 4D-STEM diffraction pattern acquisition at 30 kV, leveraging EBEAM's proven ptychographic reconstruction algorithms to achieve semi-atomic resolution of cryo-EM samples at 1/10th the cost.
Beneficiaries (4)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| DELMIC BV | NL | coordinator | €1,543,125 | Yes |
| UNIVERSITEIT ANTWERPEN | BE | participant | €503,770 | |
| ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE | CH | participant | €451,425 | |
| DELMIC CRYO BV | NL | thirdParty | €0 | Yes |
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