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ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGYbroad

OPTIPATH · Horizon Europe grant · 2025-02-01–2028-01-31

EC contribution

€3,875,952

Total cost

€3,875,952

Beneficiaries

8
About the data

Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2024-PATHFINDEROPEN-01 · scheme HORIZON-EIC · topic HORIZON-EIC-2024-PATHFINDEROPEN-01-01. CORDIS record →

Objective

Treatment decisions for many pathological conditions, including inflammatory, degenerative, autoimmune, infectious diseases, and cancer, are largely based on microscopy study of the surgically excised tissue specimens (histology). OPTIPATH provides a new paradigm for gathering objective optical tissue-dependent data, which is essential to overcoming the diagnostic challenges of inter-observer variability and limited sensitivity and specificity. OPTIPATH will offer non-destructive, label-free, real-time, 3D-presentation of tissue samples. This is enabled by (i) revolutionary nano-photonic optical metasurfaces (OMS) for simultaneous single-shot acquisition of spectral and polarimetric information, and adaptive OMS actuated by thin-film piezoelectric Micro-Electro-Mechanical-Systems (MEMS) for (ii) rapid Vector Vortex Beam (VVB) shaping of light, and (iii) rapid confocal 3D imaging. The wealth of objective diagnostic data provided will be interpreted using Machine Learning (ML) / Deep Learning (DL), and is essential to overcome inter-observer variability in diagnosis and provide actionable insights to the clinician. By utilizing optical markers present in unprepared tissue histological procedures can be dramatically sped up, offering real-time diagnosis in operation theatres and pathology departments. By offering timely and accurate diagnosis, OPTIPATH will enable early diagnosis and improved prognosis of recovery.

Beneficiaries (8)

OrganisationCountryRoleEC contributionSME
SINTEF AS NO coordinator €953,875
SYDDANSK UNIVERSITET DK participant €601,150
IDRYMA TECHNOLOGIAS KAI EREVNAS EL participant €545,000
NIL TECHNOLOGY APS DK participant €500,000 Yes
ASTON UNIVERSITY UK participant €466,290
OULUN YLIOPISTO FI participant €459,638
UNIVERSITETET I OSLO NO participant €350,000
OSLO UNIVERSITETSSYKEHUS HF NO thirdParty €0

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