Intracellular Carrier Against Resistant microOrganisms (ICARO)broad
ICARO · Horizon Europe grant · 2022-04-01–2026-09-30
EC contribution
Total cost
Beneficiaries
About the data
Source: CORDIS (official EU open data), Horizon Europe. Framework HORIZON · call HORIZON-EIC-2021-PATHFINDEROPEN-01 · scheme HORIZON-EIC · topic HORIZON-EIC-2021-PATHFINDEROPEN-01-01. CORDIS record →
Objective
Intracellular pathogens and viruses elicit immune responses by presenting their antigens to T cells. At the same time, they have evolved immune evasion mechanisms which essentially reduce the antigenic repertoire that is presented to the immune system. To overcome this problem, the EIC-funded ICARO project proposes to use silicon-based microchips that carry pathogen antigens and can be internalised by immune cells to aid antigen presentation. These biochips are retained within cells for a long time and will provide the foundation for a novel vaccination strategy that can boost specific and long-lasting T cell responses. The consortium aims to develop standardized methods for ICARO manufacturing and functionalisation to be easily applicable to different pathogens, thus accelerating the generation of new vaccines in the future
Beneficiaries (4)
| Organisation | Country | Role | EC contribution | SME |
|---|---|---|---|---|
| AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS | ES | coordinator | €1,232,520 | |
| CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR | participant | €649,900 | |
| INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM | BE | participant | €621,286 | |
| ARRAYS-FOR-CELL NANODEVICES SL | ES | participant | €493,341 | Yes |
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